技术文章
二棕榈酰磷脂酰胆碱DPPC(63-89-8)应用简介
阅读:2357 发布时间:2018-1-21二棕榈酰磷脂酰胆碱DPPC(63-89-8)应用简介:
DPPC通用名称(英文):Dipalmitoyl Phosphatidylcholine
DPPC通用名称(中文):二棕榈酰基卵磷脂
DPPC IUPAC命名:1, 2-dipalmitoyl-sn-glycero-3-phosphocholine
DPPC CAS号:63-89-8
DPPC分子量:734.0
DPPC结构式:
供应商:西安凯新生物科技有限公司
二棕榈酰磷脂酰胆碱,即DPPC,是药物制剂领域应用较为广泛的一种合成磷脂。作为活性成分,主要用于肺表面活性剂;作为辅料,可用于脂质体或温敏脂质体,以及特殊脂微球、药物复合物等药物制剂。
1、DPPC作为原料药
肺表面活性剂模拟肺表面活性物质,用于新生儿呼吸窘迫综合征可显著降低新生儿死亡率。除来源于猪肺或牛肺的天然肺表面活性剂,半合成或全合成的肺表面活性剂均需添加DPPC为主要活性物质。Discovery Laboratories Inc公司研发的Surin于2012年被FDA批准用于新生儿呼吸窘迫综合症(RDS)的预防和治疗,其处方中DPPC的含量达到65%。相对于提取来源,全合成的肺表面活性剂DPPC具有纯度高、稳定性好、无菌和不会对患儿过敏等优点。
2、DPPC作为药物辅料
2.1应用于热敏脂质体
DPPC相转变温度为41℃,因此是制备温敏脂质体的必需磷脂。Celsion公司开发的热敏脂质体ThermoDox(阿霉素热敏溶离脂质体),膜成分中含有90%的DPPC,经临床研究证实,通过联合射频消融技术,ThermoDox可使肿瘤部位阿霉素原药浓度提高10倍,从而解决了脂质体肿瘤内释药缓慢的问题,使得药物更具肿瘤靶向性。
2.2应用于微泡超声造影剂
因具有较强的降低气-液表面张力的作用,DPPC还被应用于微泡超声造影剂的包膜材料,可使气泡不易破裂,增强稳定性。如全氟丙烷脂微球混悬液Definity,其包膜材料含有DPPC 0.401mg/ml。
2.3其他
作为一种常见合成磷脂,DPPC还可以广泛应用于药物复合物、脂微球等特殊载药系统。
Abbreviation | CAS | Name |
DDPC | 3436-44-0 | 1,2-Didecanoyl-sn-Glycero-3-phosphocholine |
DEPA-NA | 80724-31-8 | 1,2-Dierucoyl-sn-Glycero-3-Phosphate(Sodium Salt) |
DEPC | 56649-39-9 | 1,2-Erucoyl-sn-Glycero-3-phosphocholine |
DEPE | 988-07-2 | 1,2-Dierucoyl-sn-Glycero-3-phosphoethanolamine |
DEPG-NA | 1,2-Dierucoyl-sn-Glycero-3[Phospho-rac-(1-glycerol...) | |
DLOPC | 998-06-1 | 1,2-Linoleoyl-sn-Glycero-3-phosphocholine |
DLPA-NA | 1,2-Dilauroyl-sn-Glycero-3-Phosphate(Sodium Salt) | |
DLPC | 18194-25-7 | 1,2-Dilauroyl-sn-Glycero-3-phosphocholine |
DLPE | 1,2-Dilauroyl-sn-Glycero-3-phosphoethanolamine | |
DLPG-NA | 1,2-Dilauroyl-sn-Glycero-3[Phospho-rac-(1-glycerol...) (Sodium Salt) | |
DLPG-NH4 | 1,2-Dilauroyl-sn-Glycero-3[Phospho-rac-(1-glycerol...) | |
DLPS-NA | 1,2-Dilauroyl-sn-Glycero-3-phosphoserine(Sodium Salt) | |
DMPA-NA | 80724-3 | 1,2-Diimyristoyl-sn-Glycero-3-Phosphate(Sodium Salt) |
DMPC | 18194-24-6 | 1,2-Dimyristoyl-sn-Glycero-3-phosphocholine |
DMPE | 988-07-2 | 1,2-Dimyristoyl-sn-Glycero-3-phosphoethanolamine |
DMPG-NA | 67232-80-8 | 1,2-Myristoyl-sn-Glycero-3[Phospho-rac-(1-glycerol...) |
DMPG-NH4 | 108321-03-5 | 1,2-Myristoyl-sn-Glycero-3[Phospho-rac-(1-glycerol...) |
DMPG-NH4/NA | 1,2-Myristoyl-sn-Glycero-3[Phospho-rac-(1-glycerol...) | |
DMPS-NA | 1,2-Dimyristoyl-sn-Glycero-3-phosphoserine(Sodium Salt) | |
DOPA-NA | 1,2-Dioleoyl-sn-Glycero-3-Phosphate(Sodium Salt) | |
DOPC | 4235-95-4 | 1,2-Dioleoyl-sn-Glycero-3-phosphocholine |
DOPE | 4004-5-1- | 1,2-Dioleoyl-sn-Glycero-3-phosphoethanolamine |
DOPG-NA | 62700-69-0 | 1,2-Dioleoyl-sn-Glycero-3[Phospho-rac-(1-glycerol...) |
DOPS-NA | 70614-14-1 | 1,2-Dioleoyl-sn-Glycero-3-phosphoserine(Sodium Salt) |
DPPA-NA | 71065-87-7 | 1,2-Dipalmitoyl-sn-Glycero-3-Phosphate(Sodium Salt) |
DPPC | 63-89-8 | 1,2-Dipalmitoyl-sn-Glycero-3-phosphocholine |
DPPE | 923-61-5 | 1,2-Dipalmitoyl-sn-Glycero-3-phosphoethanolamine |
DPPG-NA | 67232-81-9 | 1,2-Dipalmitoyl-sn-Glycero-3[Phospho-rac-(1-glycerol...) |
DPPG-NH4 | 73548-70-6 | 1,2-Dipalmitoyl-sn-Glycero-3[Phospho-rac-(1-glycerol...) |
DPPS-NA | 1,2-Dipalmitoyl-sn-Glycero-3-phosphoserine(Sodium Salt) | |
DSPA-NA | 108321-18-2 | 1,2-Distearoyl-sn-Glycero-3-Phosphate(Sodium Salt) |
DSPC | 816-94-4 | 1,2-Distearoyl-sn-Glycero-3-phosphocholine |
DSPE | 1069-79-0 | 1,2-Diostearpyl-sn-Glycero-3-phosphoethanolamine |
DSPG-NA | 67232-82-0 | 1,2-Distearoyl-sn-Glycero-3[Phospho-rac-(1-glycerol...) |
DSPG-NH4 | 108347-80-4 | 1,2-Distearoyl-sn-Glycero-3[Phospho-rac-(1-glycerol...) |
DSPS-NA | 1,2-Distearoyl-sn-Glycero-3-phosphoserine(Sodium Salt) | |
Egg Sphingomyelin empty Liposome | ||
EPC | Egg-PC | |
HEPC | Hydrogenated Egg PC | |
HSPC | High purity Hydrogenated Soy PC | |
HSPC | Hydrogenated Soy PC | |
LYSOPC MYRISTIC | 18194-24-6 | 1-Myristoyl-sn-Glycero-3-phosphocholine |
LYSOPC PALMITIC | 17364-16-8 | 1-Palmitoyl-sn-Glycero-3-phosphocholine |
LYSOPC STEARIC | 19420-57-6 | 1-Stearoyl-sn-Glycero-3-phosphocholine |
Milk Sphingomyelin MPPC | 1-Myristoyl,2-palmitoyl-sn-Glycero 3-phosphocholine | |
MSPC | 1-Myristoyl,2-stearoyl-sn-Glycero-3–phosphocholine | |
PMPC | 1-Palmitoyl,2-myristoyl-sn-Glycero-3–phosphocholine | |
POPC | 26853-31-6 | 1-Palmitoyl,2-oleoyl-sn-Glycero-3-phosphocholine |
POPE | 1-Palmitoyl-2-oleoyl-sn-Glycero-3-phosphoethanolamine | |
POPG-NA | 81490-05-3 | 1,2-Dioleoyl-sn-Glycero-3[Phospho-rac-(1-glycerol)...](Sodium Salt) |
PSPC | 1-Palmitoyl,2-stearoyl-sn-Glycero-3–phosphocholine | |
SMPC | 1-Stearoyl,2-myristoyl-sn-Glycero-3–phosphocholine | |
SOPC | 1-Stearoyl,2-oleoyl-sn-Glycero-3-phosphocholine | |
SPPC | 1-Stearoyl,2-palmitoyl-sn-Glycero-3-phosphocholine |
供应商:西安凯新生物科技有限公司