干燥设备 粉碎设备 混合设备 反应设备 过滤分离设备 过滤材料 灭菌设备 萃取设备 贮存设备 传热设备 锅炉 塔设备 结晶设备 其他制药设备
台州市科瑞生物技术有限公司
CAS号 | 864731-61-3 | 产地 | 国产 |
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分子式 | C22H17Cl2F6N3O3 | 级别 | 化工级 |
产品描述:Fluralaner是一种口服的系统性的杀虫剂和杀螨剂。
产品描述:
Fluralaner是一种口服的系统性的杀虫剂和杀螨剂。Fluralaner抑制 γ-aminobutyric acid (GABA)-gated chloride channels (GABAA receptors) 和 L-glutamate-gated chloride channels (GluCls)。
英文别名:
4-(5-(3,5-dichlorophenyl)-5-(trifluoromethyl)-4,5-dihydroisoxazol-3-yl)-2-methyl-N-(2-oxo-2-(2,2,2-trifluoroethylamino)ethyl)benzamide
Description | Fluralaner (INN) is a systemic insecticide and acaricide Fluralaner through potent blockage of GABA and L-glutamate gated chloride channels. |
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In Vitro | Fluralaner potently inhibits flea reproduction capacity in vitro. Oviposition ceases at concentrations as low as 25.0 ng/mL. While no ovicidal effect is observed, fluralaner exerts a larvicidal effect at exceptionally low concentrations (6.25 ng/mL). |
In Vivo | In the simulated flea-infested home environment, flea-control efficacy on fluralaner-treated dogs is >99% at every time point measured for 12 weeks. No adverse events are observed in fluralaner-treated dogs. Fluralaner controls egg laying, larval development and flea reproduction even at sub-insecticidal concentrations. Oral treatment of dogs with fluralaner is highly effective for eliminating fleas in a simulated flea-infested home environment[1]. After single oral administration of Bravecto chewable tablets, mite numbers in skin scrapings are reduced by 99.8% on Day 28 and by * on Days 56 and 84. A marked decrease is observed in the occurrence of erythematous patches, crusts, casts and scales in the dogs treated with Bravectco. |
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