西罗莫司

CAS号： 53123-88-9

分子式： C51H79NO13

英文名称： Sirolimus

英文同义词： Rapamycin; （-）-Rapamycin; （3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS）-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-Hexadecahydro-9,27-dihydroxy-3-（（1R）-2-（（1S,3R,4R）-4-hydroxy-3-methoxycyclohexyl）-1-methylethyl）-10,21-imethoxy-6,8,12,14,20,26-hexamethyl-23,27-epoxy-3H-pyrido（2,1-c）（1,4）oxaazacyclohentriacontine-1,5,11,28,29（4H,6H,31H）-pentone; Antibiotic AY 22989; Rapammune; 23,27-Epoxy-3H-pyrido（2,1-c）（1,4）oxaazacyclohentriacontine-1,5,11,28,29（4H,6H,31H）-pentone, 9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-9,27-dihydroxy-3-（3-（4-hydroxy-3-methoxycyclohexyl）-1-methylethyl）-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-, （3S-（3R*S*1R*,3S*,4S*））,6S*,7E,9S*,10S*,12S*,14R*,15E,17E,19E,21R*,23R*,26S*,27S*,34aR*））-; （3S,6R,7E,9R,10R,12R,14S,15E,17E,19E,21S,23S,26R,27R,34aS）-9,27-dihydroxy-3-{（2R）-1-[（1S,3R,4R）-4-hydroxy-3-methoxycyclohexyl]propan-2-yl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29（4H,6H,31H）-pentone; （3S,6R,7E,9R,10R,12R,14S,15Z,17E,19E,21S,26R,27R,34aS）-9,27-dihydroxy-3-{（1R）-2-[（1S,3R,4R）-4-hydroxy-3-methoxycyclohexyl]-1-methylethyl}-10,21-dimethoxy-6,8,12,14,20,26-hexamethyl-9,10,12,13,14,21,22,23,24,25,26,27,32,33,34,34a-hexadecahydro-3H-23,27-epoxypyrido[2,1-c][1,4]oxazacyclohentriacontine-1,5,11,28,29（4H,6H,31H）-pentone

分子量： 914.1719

沸点： 973°C at 760 mmHg

密度： 0mmHg at 25°C

闪点： 542.3°C

西罗莫司是一种大环内酯抗生素类免疫抑制剂。作为免疫抑制剂的机制在于它能阻断T 淋巴细胞活化的后期反应（增殖）抑制细胞从G1期进入S期，阻断白细胞介素-2（IL－2）与其受体的结合，使Tc、Td细胞不能成为具有免疫应答作用的致敏性T淋巴细胞，发挥其免疫作用。