E-64d Sigma
E-64d Sigma
Biochem/physiol Actions
E-64d is an epoxysuccinyl peptide and an inhibitor of cysteine protease cathepsin B,[1] calpains 1 and 2.[2] E-64d by its cathepsin B protease inhibition functionality, may serve as a potential drug for treating traumatic brain injury (TBI)[2] and Alzheimer′s disease (AD).[3] It inhibits gametocyte surface antigen resulting in a decreased oocyst production in Plasmodium falciparum.[4]
性质
Related Categories | A to C, Apoptosis Enzymes, Application Index, Autophagy, Autophagy Inhibitors, 更多... |
Quality Level | 200 |
biological source | synthetic (organic) |
assay | ≥98% (TLC) |
form | powder |
solubility | methanol: water (1:1): 5 mg/mL, clear, colorless |
storage temp. | −20°C |
SMILES string | CCOC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCCC(C)C |
InChI | 1S/C17H30N2O5/c1-6-23-17(22)14-13(24-14)16(21)19-12(9-11(4)5)15(20)18-8-7-10(2)3/h10-14H,6-9H2,1-5H3,(H,18,20)(H,19,21)/t12-,13-,14-/m0/s1 |
InChI key | SRVFFFJZQVENJC-IHRRRGAJSA-N |
Gene Information | human ... CAPN1(823) |
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