HY-B2176-Adenosine 5'-triphosphate试剂-杭州昊鑫生物科技股份有限公司

Adenosine 5'-triphosphate试剂返回列表页

参考价:￥500 - ￥800

具体成交价以合同协议为准

型号
HY-B2176
品牌
MCE
厂商性质
代理商
所在地
杭州市

规格

100 mg 500元 10000支可售

500 mg 800元 10000支可售

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更新时间：2023-05-22 15:20:35浏览次数：166次

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产地	进口	级别	其他

注：本产品仅用于科研，不可用于临床

生物活性

ATP (Adenosine 5'-triphosphate) is a central component of energy storage and metabolism in vivo. ATP provides the metabolic energy to drive metabolic pumps and serves as a coenzyme in cells. ATP is an important endogenous signaling molecule in immunity and inflammation^[1]^[2].

IC₅₀ & Target

Human Endogenous Metabolite

体外研究
(In Vitro)

ATP (5 mM; 1 hour) co-treatment with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs^[3].
ATP (2 mM; 0.5-24 hours) induces secretion of IL-1β, KC and MIP-2 from BMDMs in a caspase-1 activation-dependent manner^[4].
ATP promotes neutrophil chemotaxis in vitro^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

体内研究
(In Vivo)

ATP (50 mg/kg; i.p.) protects mice against bacterial infection in vivo^[4].
ATP induces the secretion of IL-1β, KC and MIP-2 and neutrophils recruitment in vivo^[4].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Four-week-old Kunming mice (18-22 g)^[4]
Dosage:	50 mg/kg
Administration:	Intraperitoneal injection, before bacterial (E. coli) challenge
Result:	Protected mice from bacterial infection.

分子量

507.18

性状

Solid

Formula

C₁₀H₁₆N₅O₁₃P₃

CAS 号

56-65-5

中文名称

腺苷三磷酸

结构分类

Alkaloids
Other Alkaloids

来源

Plants
other families

widespread

运输条件

Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

H₂O : ≥ 100 mg/mL (197.17 mM)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	1.9717 mL	9.8584 mL	19.7169 mL
5 mM	0.3943 mL	1.9717 mL	3.9434 mL
10 mM	0.1972 mL	0.9858 mL	1.9717 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： PBS
Solubility: 100 mg/mL (197.17 mM); Clear solution; Need ultrasonic and warming and heat to 60°C

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