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Recombinant Human GM-CSF 货号:AF-300-03 细胞因子

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更新时间:2016-01-17 21:25:58浏览次数:6697次

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Recombinant Human GM-CSF 货号:AF-300-03 细胞因子
细胞因子(cytokine,CK)是一类能在细胞间传递信息、具有免疫调节和效应功能的蛋白质或小分子多肽。
作用特点:多效性、重叠性、协同性、拮抗性和双重性。

详细介绍

Recombinant Human GM-CSF 货号:AF-300-03 细胞因子 

细胞因子受体的结构和分类:根据细胞因子受体cDNA序列以及受体胞膜外区氨基酸序列的同源性和结构征,可将细胞因子受体主要分为四种类型:免疫球蛋白超家族(IGSF)、造血细胞因子受体超家族、神经生长因子受体超家族和趋化因子受体。

 

Catalog Number:
AF-300-03
Synonyms:
Granulocyte/Macrophage Colony-Stimulating Factor, CSF-2, MGI-1GM, pluripoietin-alpha
Description:
GM-CSF is a hematopoietic growth factor that stimulates the development of neutrophils and macrophages and promotes the proliferation and development of early erythroid megakaryocytic and eosinophilic progenitor cells. It is produced in endothelial cells, monocytes, fibroblasts and T-lymphocytes. GM-CSF inhibits neutrophil migration and enhances the functional activity of the mature end-cells. The human and murine molecules are species-specific and exhibit no cross-species reactivity. Recombinant human GM-CSF is a 14.6 kDa globular protein consisting of 128 amino acids containing two intramolecular disulfide bonds and two potential N-linked glycosylation sites. Manufactured using all non-animal reagents.
AA Sequence:
MAPARSPSPS TQPWEHVNAI QEARRLLNLS RDTAAEMNET VEVISEMFDL QEPTCLQTRL ELYKQGLRGS LTKLKGPLTM MASHYKQHCP PTPETSCATQ IITFESFKEN LKDFLLVIPF DCWEPVQE
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
The ED50 was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is ≤ 0.1 ng/ml, corresponding to a specific activity of ≥ 1 x 107 units/mg.
 
 
 
 
Cross Reactivity:
Human, Mouse
Research Interests:
Cancer Cancer Cell Culture Cell Culture
Inflammation Inflammation Proliferation Proliferation
Stem Cells & Differentiation Stem Cells & Differentiation Wound Healing Wound Healing
 
 
Country of Origin:
USA


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