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Recombinant Human IFN-r 货号:300-02 细胞因子

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更新时间:2016-01-16 15:34:23浏览次数:7348次

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Recombinant Human IFN-r 货号:300-02 细胞因子
细胞因子(cytokine,CK)是一类能在细胞间传递信息、具有免疫调节和效应功能的蛋白质或小分子多肽。
作用特点:多效性、重叠性、协同性、拮抗性和双重性。

详细介绍

Recombinant Human IFN-r 货号:300-02 细胞因子 

 

细胞因子受体的结构和分类:根据细胞因子受体cDNA序列以及受体胞膜外区氨基酸序列的同源性和结构征,可将细胞因子受体主要分为四种类型:免疫球蛋白超家族(IGSF)、造血细胞因子受体超家族、神经生长因子受体超家族和趋化因子受体。

 

Catalog Number:
300-02
Synonyms:
Immune Interferon, type II interferon, T cell interferon, MAF
Description:
IFN-γ is an acid-labile interferon produced by CD4 and CD8 T lymphocytes as well as activated NK cells. IFN-γ receptors are present in most immune cells, which respond to IFN-γ signaling by increasing the surface expression of class I MHC proteins. This promotes the presentation of antigen to T-helper (CD4+) cells. IFN-γ signaling in antigen-presenting cells and antigen-recognizing B and T lymphocytes regulate the antigen-specific phases of the immune response. Additionally, IFN-γ stimulates a number of lymphoid cell functions including the anti-microbial and anti-tumor responses of macrophages, NK cells, and neutrophils. Human IFN-γ species-specific and is biologically active only in human and primate cells. Recombinant human IFN-γ is a 16.7 kDa protein containing 143 amino acid residues.
AA Sequence:
MQDPYVKEAE NLKKYFNAGH SDVADNGTLF LGILKNWKEE SDRKIMQSQI VSFYFKLFKN FKDDQSIQKS VETIKEDMNV KFFNSNKKKR DDFEKLTNYS VTDLNVQRKA IHELIQVMAE LSPAAKTGKR KRSQMLFQGR RASQ
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Assay #1: Determined by its ability to induce apoptosis in HeLa cells. The expected ED50 for this effect is 5.0-10.0 ng/ml.
Assay #2: The ED50 was determined by a cytotoxicity assay using HT-29 cells is ≤ 0.05 ng/ml, corresponding to a specific activity of ≥ 2 x 107 units/mg.
 
 
 
 
Cross Reactivity:
Monkey, Human, Mouse, Leech, Pig, Human + Bacteria
Research Interests:
AIDS /  HIV AIDS / HIV Angiogenesis/ Cardiovascular Angiogenesis/ Cardiovascular
Cancer Cancer Diabetes /  Weight Regulation Diabetes / Weight Regulation
Immune System Immune System Neurobiology Neurobiology
Stem Cells & Differentiation Stem Cells & Differentiation Allergy Allergy
Transplantation Transplantation  
 
 
Country of Origin:
USA


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