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Recombinant Human IGF-1 货号:100-11 细胞因子

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产品简介

Recombinant Human IGF-1 货号:100-11 细胞因子
细胞因子(cytokine,CK)是一类能在细胞间传递信息、具有免疫调节和效应功能的蛋白质或小分子多肽。
作用特点：多效性、重叠性、协同性、拮抗性和双重性。

详细介绍

Recombinant Human IGF-1 货号:100-11 细胞因子

细胞因子受体的结构和分类:根据细胞因子受体cDNA序列以及受体胞膜外区氨基酸序列的同源性和结构征，可将细胞因子受体主要分为四种类型：免疫球蛋白超家族（IGSF）、造血细胞因子受体超家族、神经生长因子受体超家族和趋化因子受体。

Catalog Number:

100-11

Synonyms:

Insulin-like Growth Factor-I, Somatamedin C, IGF-IA

Description:

The IGFs are mitogenic polypeptide growth factors that stimulate the proliferation and survival of various cell types including muscle, bone, and cartilage tissue in vitro. IGFs are predominantly produced by the liver, although a variety of tissues produce the IGFs at distinctive times. The IGFs belong to the Insulin gene family, which also contains insulin and relaxin. The IGFs are similar by structure and function to insulin, but have a much higher growth-promoting activity than insulin. IGF-II expression is influenced by placenta lactogen, while IGF-I expression is regulated by growth hormone. Both IGF-I and IGF-II signal through the tyrosine kinase type I receptor （IGF-IR）, but, IGF-II can also signal through the IGF-II/Mannose-6-phosphate receptor. Mature IGFs are generated by proteolytic processing of inactive precursor proteins, which contain N-terminal and C-terminal propeptide regions. Recombinant human IGF-I and IGF-II are globular proteins containing 70 and 67 amino acids, respectively, and 3 intra-molecular disulfide bonds.

AA Sequence:

GPETLCGAEL VDALQFVCGD RGFYFNKPTG YGSSSRRAPQ TGIVDECCFR SCDLRRLEMY CAPLKPAKSA

Source:

E.coli

Purity:

Greater than 98% by SDS-PAGE gel and HPLC analyses.

Biological Activity:

The ED50 was determined by a cell proliferation assay using FDC-P1 cells is ≤ 2.0 ng/ml, corresponding to a specific activity of ≥ 5 x 105 units/mg.

Cross Reactivity:

Bacteria, Chicken, Cow, Frog, Horse, Monkey, Mouse, Pig, Rat, Sheep, Tiger Salamander, Hamster, Human, N/A

Research Interests: