TAMRA-Azide-Desthiobiotin

Desthiobiotin is a single-ring, sulfur-free analog of biotin that binds to streptavidin with nearly equal specificity but less affinity than biotin (K_d = 10¹¹ vs. 10¹⁵M, respectively). Consequently, desthiobiotinylated proteins can be eluted readily and specifically from streptavidin affinity resin using mild conditions based on competitive displacement with free biotin. For pull-down experiments with biological samples, this soft-release characteristic of desthiobiotin also helps to minimize co-purification of endogenous biotinylated molecules, which remain bound to streptavidin upon elution of the target protein complexes with free biotin.

Molecular weight	1145.33
Chemical composition	C57H82N11O14
CAS	N/A
Solubility	DMSO, DMF, DCM, THF, Chloroform
Purity	>95%
Appearance	Red amorphous solid to red oil
Storage conditions	-20C
Shipping conditions	Ambient temperature

Desthiobiotin是一种单环、无硫生物素的类似物，它与链霉菌素结合的特异性几乎相同，但亲和力却不如生物素(Kd分别为1011和1015M)。因此，在与自由生物素竞争驱替的温和条件下，可以很容易地、特别地从链霉毒素亲和树脂中分离出脱硫生物素。在生物样品的下拉实验中，desthiobiotin的软释放特性也有助于减少内源性生物素化分子的共提纯，这些分子在游离生物素的目标蛋白复合物的洗脱作用下仍与链球菌肽结合。

分子量	1145.33
分子式	C57H82N11O14
CAS	N/A
溶解度	DMSO, DMF, DCM, THF, Chloroform
含量	>95%
外观	红色无定形固体或红油色有油质
储存	-20C
运输	环境温度

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Click Chemistry Tool

DBCO Reagents

Amine Reactive

DBCO-C6-NHS Ester

• DBCO-NHS Ester
• DBCO-Sulfo-NHS Ester
• DBCO-PEG4-NHS Ester
• DBCO-PEG5-NHS Ester
• DBCO-PEG13-NHS Ester
• PC DBCO-NHS Ester
• DBCO-C6-Acid
• DBCO-Acid
• DBCO-PEG5-Acid

Carboxyl/Carbonyl Reactive

• DBCO-Amine
• DBCO-PEG4-Amine
• Sulfo DBCO-PEG4-Amine
• Sulfo DBCO-Amine

 Sulfhydryl Reactive

• Sulfo DBCO-Maleimide

DBCO-Maleimide

• Sulfo DBCO-PEG4-Maleimide
• DBCO-PEG4-Maleimide
• Bis-sulfone-PEG4-DBCO
• ThioLinker-DBCO

Fluorescent Probes

• MB 532 DBCO

MB 488 DBCO

• MB 543 DBCO
• MB 594 DBCO
• Carboxyrhodamine 110 DBCO
• TAMRA DBCO
• Cy3 DBCO
• Cy5 DBCO
• Cy5.5 DBCO
• Cy7 DBCO

 Biotinylation Reagents

• DBCO-PEG4-Biotin

WS DBCO-Biotin

• DBCO-PEG4-Desthiobiotin
• Dde Biotin-DBCO
• PC DBCO-Biotin
• WS PC DBCO-Biotin
• Diazo Biotin-DBCO

PEGylation Reagents

• DBCO-mPEG, 5 kDa

DBCO-mPEG, 10 kDa

• DBCO-mPEG, 20 kDa
• DBCO-mPEG, 30 kDa

 Bifunctional Crosslinkers

• Methyltetrazine-DBCO

Methyltetrazine-PEG12-DBCO

• DBCO-PEG4-DBCO
• TCO-PEG12-DBCO

 Miscellaneous Reagents

• DBCO-PEG4-Hydroxyl