| 中文名 | 帕拉米韦 |
|---|---|
| 英文名 | peramivir |
| 中文别名 | 帕拉米韦三水合物 |
| 英文别名 | 更多 |
| 描述 | Peramivir (RWJ 270201; Rapiacta; BCX 1812)是高活性的流感病毒神经氨酸苷酶抑制剂，IC50的中位值为0.09 nM。 |
|---|---|
| 相关类别 | 信号通路 >> 抗感染 >> 流感病毒 研究领域 >> 感染 |
| 参考文献 | [1]. Louie JK, Yang S, Yen C, Acosta M, Schechter R, Uyeki TM.Use of Intravenous Peramivir for Treatment of Severe Influenza A(H1N1)pdm09.PLoS One. 2012;7(6):e40261. [2]. Sakata H.Clinical efficiency in children treated with intravenous drip infusion of peramivirJpn J Antibiot. 2011 Dec;64(6):383-7. [3]. Abed Y, Pizzorno A, Boivin G.Therapeutic Activity of Intramuscular Peramivir in Mice Infected with a Recombinant Influenza A/WSN/33 (H1N1) Virus Containing the H275Y Neuraminidase Mutation.Antimicrob Agents Chemother. 2012 Aug;56(8):4375-80. [4]. Shobugawa Y, Saito R, Sato I, Kawashima T, Dapat C, Dapat IC, Kondo H, Suzuki Y, Saito K, Suzuki H.Clinical effectiveness of neuraminidase inhibitors-oseltamivir, zanamivir, laninamivir, and peramivir-for treatment of influenza A(H3N2) and A(H1N1)pdm09 infection: an observational study in the 2010-2011 influenza season in Japan.J Infect Chemother. 2012 May 29. [5]. Yu Y, Garg S, Yu PA, Kim HJ, Patel A, Merlin T, Redd S, Uyeki TM.Peramivir use for treatment of hospitalized patients with influenza A(H1N1)pdm09 under emergency use authorization, October 2009-June 2010.Clin Infect Dis. 2012 Jul;55(1):8-15. |
| 分子式 | C15H34N4O7 |
|---|---|
| 分子量 | 382.453 |
| 精确质量 | 382.242737 |
| PSA | 179.71000 |
| LogP | 1.69890 |
| Rapiacta trihydrate |
| Peramivir Trihydrate |
| QW7Y7ZR15U |
| peramivir hydrate |
| BCX 1812 trihydrate |
| CS-0732 |
| UNII-QW7Y7ZR15U |
| (1S,2S,3S,4R)-3-[(1S)-1-acetamido-2-ethylbutyl]-4-(diaminomethylideneamino)-2-hydroxycyclopentane-1-carboxylic acid,trihydrate |
| (1S,2S,3S,4R)-3-[(1S)-1-Acetamido-2-ethylbutyl]-4-[(diaminomethylene)amino]-2-hydroxycyclopentanecarboxylic acid trihydrate |
| Cyclopentanecarboxylic acid, 3-[(1S)-1-(acetylamino)-2-ethylbutyl]-4-[(diaminomethylene)amino]-2-hydroxy-, (1S,2S,3S,4R)-, hydrate (1:3) |
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