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IGF-I/IGF-1 蛋白, Human (70a.a)

参考价	￥500.00

参考价

￥500.00

具体成交价以合同协议为准

公司名称杭州昊鑫生物科技股份有限公司
品牌MCE
型号HY-P7018
所在地杭州市
厂商性质代理商
更新时间2024/6/24 15:41:08
访问次数141

产品标签:

70a.a

规格

10ug

500.00元

10000 支可售

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杭州昊鑫生物科技股份有限公司成立于2009年初，是一家面向生命科学领域，从事科研机构、高校、院所及生产企业所需科研试剂、耗材，仪器销售和服务面向全国。

产品和服务涵盖生命科学研究技术的诸多方面，提供覆盖分子生物学、细胞生物学、植物学、生物化学、蛋白组学、免疫学等领域的实验产品以及生物技术服务等。目前一级代理品牌有：MCE（Medchemexpress）、Biochannel、AATbio、invivogen、Abnova、Atlas、Origene、Biovision、云克隆（Cloud-clone）、艾德莱(Aidlab)、Cayman、Jackson、Epigentek、Prospec、Sciencell、icellbioscience（赛百慷）、hkABCbio、chondrex、Mybiosource、Abbexa、Innovrsrch、HPI、Hitobiotec、Greerlabs，Ostex，4ADI，LDN等。

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产地	国产	规格	10ug
级别	化工级	证书	ISO系列证书

IGF-I/IGF-1 蛋白, Human (70a.a)是一种促进有丝分裂的细胞因子，与 IGF 受体结合，能够调节多种组织的生长，如神经组织、淋巴组织、生殖组织、平滑肌、内皮细胞和骨骼等，同时具有调节神经保护的作用。

IGF-I/IGF-1 蛋白, Human (70a.a) 产品信息

IGF-I/IGF-1 蛋白, Human (70a.a)

IGF-I/IGF-1 蛋白, Human (70a.a)是一种促进有丝分裂的细胞因子，与 IGF 受体结合，能够调节多种组织的生长，如神经组织、淋巴组织、生殖组织、平滑肌、内皮细胞和骨骼等，同时具有调节神经保护的作用。

描述

IGF-I/IGF-1 Protein, Human (70a.a) is a mitogenic cytokine, binds to IGF type 1 receptor, and modulates growth in many tissues, such as nervous tissue, lymphoid tissue, reproductive tissue, smooth muscle, endothelium, and bone; IGF-I/IGF-1 Protein also mediates neuroprotective mechanism.

研究背景

Insulin-like growth factor (IGF) system has been shown to modulate growth in many tissues, such as nervous tissue, lymphoid tissue, reproductive tissue, smooth muscle, endothelium, and bone. Insulin-like Growth factor-1 (IGF-I) is produced by osteoblasts, and its mitogenic effects are mediated by their binding to the IGF plasma membrane receptors. The IGF type 1 receptor binding to both IGF-I and IGF-II, is thought to be the predominate receptor involved in mediating the effects of these growth factors in most cell types, including osteoblasts^[1]. Insulin-like growth factor-1 (IGF-1) is a neurotrophic factor capable of mediating neuroprotective and neuroplasticity mechanisms. Targeted overexpression of IGF-1 enhances the generation of hippocampal newborn neurons in brain-injured mice^[2].

种属：Human

表达系统：E. coli

标签：Tag Free

蛋白编号：P05019 (G49-A118)

基因 ID：3479 [NCBI]

同用名：rHuIGF-1; IGF-IA; Somatamedin C; MGF; IGF-I

氨基酸序列

GPETLCGAELVDALQFVCGDRGFYFNKPTGYGSSSRRAPQTGIVDECCFRSCDLRRLEMYCAPLKPAKSA

分子量：Approximately 7.7 kDa

纯度：Greater than 95% as determined by reducing SDS-PAGE.

性状：Lyophilized powder.

组分：Lyophilized after extensive dialysis against PBS.

复溶方法：It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH₂O.

保存条件 & 期限

Stored at -20°C. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer. It is recommended to freeze aliquots at -20°C or -80°C for extended storage.

运输条件

Room temperature in continental US; may vary elsewhere.

参考文献

[1]. Richman C, et al. Recombinant human insulin-like growth factor-binding protein-5 stimulates bone formation parameters in vitro and in vivo. Endocrinology. 1999 Oct;140(10):4699-705. [Content Brief]
[2]. Carlson SW, et al. Central Infusion of Insulin-Like Growth Factor-1 Increases Hippocampal Neurogenesis and Improves Neurobehavioral Function after Traumatic Brain Injury. J Neurotrauma. 2018 Jul 1;35(13):1467-1480. [Content Brief]

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