Recombinant Human TSLP 货号:300-62 细胞因子
胞因子受体存在着可溶性形式，掌握可溶性细胞因子受体产生的规律及其生理和病理意义，必将扩展人们对细胞因子网络作用的认识。检测细胞因子及其受体的水平已成为基础和临床免疫学研究中的一个重要的方面。Catalog Number:
Catalog Number:
300-62
Synonyms:
Thymic Stromal Lymphopoietin
Description:
TSLP is a hemopoietic protein that is expressed in the heart, liver and prostate. TSLP overlaps biological activities with IL-7 and binds with the heterodimeric receptor complex consisting of the IL-7R α chain （IL-7Rα） and the TSLP-specific chain （TSLPR）. Like IL-7, TSLP induces phosphorylation of STAT3 and STAT5, but uses kinases other than the JAKs for activation. TSLP prohibited apoptosis and stimulated growth of the human acute myeloid leukemia （AML）-derived cell line MUTZ3. It induces the release of T cell-attracting chemokines TARC and MDC from monocytes and activates CD11c（+） dendritic cells （DCs）. TSLP activated DCs primed naïve T cells to produce the proallergic cytokines （IL-4, IL-5, IL-13, TNFα） while down-regulating IL-10 and IFN-γ suggesting a role in initiating allergic inflammation. Recombinant human TSLP is a 15.0 kDa protein consisting of 132 amino acid residues.
AA Sequence:
MYDFTNCDFE KIKAAYLSTI SKDLITYMSG TKSTEFNNTV SCSNRPHCLT EIQSLTFNPT AGCASLAKEM FAMKTKAALA IWCPGYSETQ INATQAMKKR RKRKVTTNKC LEQVSQLQGL WRRFNRPLLK
Source:
E.coli
Purity:
Greater than 98% by SDS-PAGE gel and HPLC analyses.
Biological Activity:
Data not available at this time.
Cross Reactivity:
Mouse, Human
Research Interests:
 | Apoptosis |  | Inflammation |
Country of Origin:
USA
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