Methoprene (Synonyms: 烯虫酯; ZR-515)
Methoprene 是一种昆虫幼年生长ji素的模拟物，是一种生长调节杀虫剂，通过作为幼年ji素 (juvenile hormone) 激动剂来显示其对靶生物的毒性。
生物活性
Methoprene, an insect juvenile growth hormone mimic, is a growth-regulating insecticide that manifests its toxicity to target organisms by acting as a juvenile hormone agonist[1][2].
体外研究(In Vitro)
Methoprene reduces the growth rate of daphnids with evidence of only a single concentration-response line, having a threshold of 12.6 nM. Molt frequency is reduced by methoprene in a concentration-dependent manner, with a response curve corresponding to a 2-segmented line and thresholds at 4.2 and 0.21 nM. An endpoint related to reproductive maturation, the time of first brood deposition, is also affected by methoprene, with a clear concentration-dependent response and a NOEC of 32 nM. Methoprene reduces fecundity according to a 2-segmented line, with thresholds of 24 and < or =0.18 nM. Methoprene elicits significant toxicity to endocrine-related processes in the 5-50 nM concentration range[1].
分子量：310.47
性状：Liquid
Formula：C19H34O3
CAS 号：40596-69-8
中文名称：烯虫酯；烯虫丙酯；甲氧普烯；甲氧普林
运输条件
Room temperature in continental US; may vary elsewhere.
储存方式
| Pure form | -20°C | 3 years |
|---|---|---|
| 4°C | 2 years | |
| In solvent | -80°C | 6 months |
| -20°C | 1 month |
溶解性数据
Ethanol : 100 mg/mL (322.09 mM; Need ultrasonic)
Acetone : ≥ 50 mg/mL (161.05 mM)
DMSO : 25 mg/mL (80.52 mM; Need ultrasonic)
* "≥" means soluble, but saturation unknown.
| 浓度溶剂体积质量 | 1 mg | 5 mg | 10 mg |
|---|
| 1 mM | 3.2209 mL | 16.1046 mL | 32.2092 mL |
| 5 mM | 0.6442 mL | 3.2209 mL | 6.4418 mL |
| 10 mM | 0.3221 mL | 1.6105 mL | 3.2209 mL |
请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。
请根据您的实验动物和给药方式选择适当的溶解方案。以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：
——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用； 以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶
- 1.
请依序添加每种溶剂： 10% DMSO 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (8.05 mM); Clear solution
- 2.
请依序添加每种溶剂： 10% DMSO 90% (20% SBE-β-CD in saline)
Solubility: 2.5 mg/mL (8.05 mM); Suspended solution; Need ultrasonic
- 3.
请依序添加每种溶剂： 10% DMSO 90% corn oil
Solubility: ≥ 2.5 mg/mL (8.05 mM); Clear solution
- 4.
请依序添加每种溶剂： 10% EtOH 40% PEG300 5% Tween-80 45% saline
Solubility: ≥ 2.5 mg/mL (8.05 mM); Clear solution
- 5.
请依序添加每种溶剂： 10% EtOH 90% (20% SBE-β-CD in saline)
Solubility: ≥ 2.5 mg/mL (8.05 mM); Suspended solution
- 6.
请依序添加每种溶剂： 10% EtOH 90% corn oil
Solubility: ≥ 2.5 mg/mL (8.05 mM); Clear solution
参考文献
[1]. Olmstead AW, LeBlanc GL. Low exposure concentration effects of methoprene on endocrine-regulated processes in the crustacean Daphnia magna. Toxicol Sci. 2001;62(2):268-273. [Content Brief]
[2]. Monteiro JP, et al. Toxicity of methoprene as assessed by the use of a model microorganism. Toxicol In Vitro. 2005;19(7):951-956. [Content Brief]
注：产品仅用于科研
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