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Butylhydroxyanisole (丁基羟基茴香醚)

参考价	￥400.00

参考价

￥400.00

具体成交价以合同协议为准

公司名称杭州昊鑫生物科技股份有限公司
品牌MCE
型号HY-B1066
所在地杭州市
厂商性质代理商
更新时间2024/6/24 15:51:40
访问次数156

产品标签:

丁基羟基茴香醚

规格

500mg

400.00元

10000 支可售

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杭州昊鑫生物科技股份有限公司成立于2009年初，是一家面向生命科学领域，从事科研机构、高校、院所及生产企业所需科研试剂、耗材，仪器销售和服务面向全国。

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产品简介在线询价

CAS号	25013-16-5	产地	国产
规格	500mg	级别	化工级
证书	ISO系列证书

Butylhydroxyanisole (Butylated hydroxyanisole) 是一种抗氧化剂，用作食品防腐剂。Butylhydroxyanisole 能介导肝毒性、生殖qi官发育和学习迟缓以及睡眠不足。Butylhydroxyanisole 具有神经毒性，能导致大脑和神经发育中断。Butylhydroxyanisole 也是一个铁死亡 (ferroptosis) 诱导剂。

Butylhydroxyanisole (丁基羟基茴香醚) 产品信息

Butylhydroxyanisole (Synonyms: 丁基羟基茴香醚; Butylated hydroxyanisole; BHA; E320)

生物活性

Butylhydroxyanisole (Butylated hydroxyanisole) is an antioxidant used as a food additive preservative. Butylhydroxyanisole mediates liver toxicity, retardation in reproductive organ development and learning, and sleep deficit. Butylhydroxyanisole exerts neurotoxic effects and leads to disruption of the brain and nerve development^[1]^[2]^[3]. Butylhydroxyanisole is a ferroptosis inducer^[4].

体外研究(In Vitro)

Butylhydroxyanisole exerts neurotoxic effects by promoting cytosolic calcium accumulation and endoplasmic reticulum stress in astrocytes^[1].

Butylhydroxyanisole (25-100 μM; 48 hours) inhibits growth and induces death in human astrocytes^[1].
Butylhydroxyanisole (100 μM; 48 hours) decreases the expression of cell-cycle-related proteins and increased the expression of the cell cycle inhibitory protein^[1].
Butylhydroxyanisole (100 μM; 48 hours) mediates apoptotic signals in NHA-SV40LT Cells^[1].
Butylhydroxyanisole also increases the cytosolic calcium level and the expression of endoplasmic reticulum stress proteins^[1].
Butylhydroxyanisole induces testicular dysfunction in mouse testis cells by dysregulating calcium homeostasis and stimulating endoplasmic reticulum stress^[2].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Cell Proliferation Assay^[1]

Cell Line:	NHA-SV40LT cells
Concentration:	0 μM, 25 μM, 50 μM, 75 μM, 100 μM
Incubation Time:	48 hours
Result:	Exerted antiproliferative effects.

体内研究(In Vivo)

Butylhydroxyanisole (200 mg/kg; i.g.; daily; for three days) induces distinct expression patterns of Nrf2 and detoxification enzymes in the liver and small intestine of C57BL/6 mice^[3].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Five-week-old C57BL/6 mice (WT and Nrf2^-/-)^[3]
Dosage:	200 mg/kg
Administration:	Oral gavage, daily, for three days
Result:	Increased Nqo1 staining in hepatocytes, predominately in the pericentral region.

Clinical Trial

NCT Number	Sponsor	Condition	Start Date	Phase
NCT05094817	Women´s College Hospital\|University Health Network, Toronto	Delirium in Old Age\|Alzheimer Disease\|Mild Cognitive Impairment\|Neurocognitive Disorders	February 11, 2022
NCT03826784	Carmell Therapeutics Corporation	Tibial Fractures	November 2019	Phase 3
NCT04056429	Carmell Therapeutics Corporation	Tibial Fractures	July 2020	Phase 2

分子量：180.24

性状：Solid

Formula：C₂₂H₃₂O₄

CAS 号：25013-16-5

中文名称：丁基羟基茴香醚；叔丁基对羟基茴香醚；丁基大茴醚

运输条件：Room temperature in continental US; may vary elsewhere.

储存方式

Powder	-20°C	3 years
	4°C	2 years
In solvent	-80°C	6 months
	-20°C	1 month

溶解性数据

In Vitro:

DMSO : ≥ 100 mg/mL (554.82 mM)

H₂O : 1 mg/mL (5.55 mM; ultrasonic and warming and heat to 60°C)

* "≥" means soluble, but saturation unknown.

配制储备液

浓度溶剂体积质量	1 mg	5 mg	10 mg

1 mM	5.5482 mL	27.7408 mL	55.4816 mL
5 mM	1.1096 mL	5.5482 mL	11.0963 mL
10 mM	0.5548 mL	2.7741 mL	5.5482 mL

请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。
储备液的保存方式和期限：-80°C, 6 months; -20°C, 1 month。-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。

In Vivo:

以下溶解方案都请先按照 In Vitro 方式配制澄清的储备液，再依次添加助溶剂：

——为保证实验结果的可靠性，澄清的储备液可以根据储存条件，适当保存；体内实验的工作液，建议您现用现配，当天使用；以下溶剂前显示的百
分比是指该溶剂在您配制终溶液中的体积占比；如在配制过程中出现沉淀、析出现象，可以通过加热和/或超声的方式助溶

1.

请依序添加每种溶剂： PBS
Solubility: 100 mg/mL (554.82 mM); Clear solution; Need ultrasonic

参考文献

[1]. Sunwoo Park, et al. Butylated Hydroxyanisole Exerts Neurotoxic Effects by Promoting Cytosolic Calcium Accumulation and Endoplasmic Reticulum Stress in Astrocytes. J Agric Food Chem. 2019 Aug 28;67(34):9618-9629.  [Content Brief]
[2]. Jiyeon Ham, et al. Butylated Hydroxyanisole Exerts Neurotoxic Effects by Promoting Cytosolic Calcium Accumulation and Endoplasmic Reticulum Stress in Astrocytes. Sci Total Environ. 2020 Feb 1;702:134775.  [Content Brief]
[3]. Lin Luo, et al. Butylated hydroxyanisole induces distinct expression patterns of Nrf2 and detoxification enzymes in the liver and small intestine of C57BL/6 mice. Toxicol Appl Pharmacol. 2015 Nov 1;288(3):339-48.  [Content Brief]
[4]. Jennifer Yinuo Cao, et al. Mechanisms of ferroptosis. Cell Mol Life Sci. 2016 Jun;73(11-12):2195-209.  [Content Brief]

注：产品仅用于科研

关键词：防腐剂